Dental News - Newly created protein may be promising for anti-caries vaccine

Dental Tribune International

Tue. 10. October 2017

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WUHAN, China: Researchers from the Wuhan Institute of Virology at the Chinese Academy of Sciences have created a fusion protein (formed through the joining of genes that originally coded for separate proteins) that might be the key to developing a vaccine against dental caries. According to the research team, their second-generation fusion protein provides high protective efficacy against caries, but with lower side-effects than with previously created proteins.

The research, which was supported by grants from the National Natural Science Foundation of China and the German Research Foundation, is an advancement on previous studies on the fusion protein KF-rPAc. While KF-rPAc provided prophylactic and therapeutic efficiency against caries, it also demonstrated possible side-effects, such as high antigenicity and potential inflammatory injury, that restricted its clinical usage.

Aiming to avoid these drawbacks, the researchers created KFD2-rPAc, which induced fewer systemic inflammatory responses in animal trials, among other effects. Although there is still a long way to go until a vaccine for use in humans will be available, the characteristics of KFD2-rPAc make the protein a promising vaccine candidate against dental caries, the researchers concluded.

The results were published in a paper titled “Second-generation flagellin-rPAc fusion protein, KFD2-rPAc, shows high protective efficacy against dental caries with low potential side effects” on 11 September in the Scientific Reports journal.

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