Researchers link use of antibiotics to Parkinson’s disease

Dental Tribune International

Fri. 29. November 2019

save

HELSINKI, Finland: Antibiotic overprescribing continues to be a major concern in dentistry. In most cases, readily prescribing antibiotics to patients before a dental treatment does not ensure effective and appropriate dental care intervention. Additionally, it accelerates antibiotic resistance. A recent study has found that higher exposure to commonly used oral antibiotics, especially broad-spectrum antibiotics and those that act against anaerobic bacteria and fungi, may also increase the risk of developing Parkinson’s disease.

In a case-control study, the researchers extracted data from national registries and compared antibiotic exposure between 1998 and 2014 in 13,976 Parkinson’s disease patients with 40,697 non-affected persons matched for age, sex and place of residence. Antibiotic exposure was examined over three different periods: one to five years, five to ten years and ten to 15 years before the index date, based on oral antibiotic purchase data.

Owing to the disruptive effects of antibiotics on the gut microbial ecosystem, the findings suggested that excessive use of certain antibiotics can predispose patients to Parkinson’s disease, with a delay of up to ten to 15 years.

“The link between antibiotic exposure and Parkinson’s disease fits the current view that in a significant proportion of patients the pathology of Parkinson’s may originate in the gut, possibly related to microbial changes, years before the onset of typical Parkinson motor symptoms such as slowness, muscle stiffness and shaking of the extremities,” said lead author Dr Filip Scheperjans, a neurologist from Helsinki University Hospital based at the Neurocenter at Meilahti Hospitals in Helsinki.

“It was known that the bacterial composition of the intestine in Parkinson’s patients is abnormal, but the cause is unclear. Our results suggest that some commonly used antibiotics, which are known to strongly influence the gut microbiota, could be a predisposing factor.”

In the gut, pathological changes typical of Parkinson’s disease have been observed up to 20 years before diagnosis. The researchers have also associated symptoms such as constipation, irritable bowel syndrome and inflammatory bowel disease with a higher risk of developing the disease. Exposure to antibiotics has been shown to cause changes in the gut microbiome and their use was associated with an increased risk of several diseases, such as psychiatric disorders, Crohn’s disease and Parkinson’s.

“The discovery may also have implications for antibiotic prescribing practices in the future. In addition to the problem of antibiotic resistance, antimicrobial prescribing should also take into account their potentially long-lasting effects on the gut microbiome and the development of certain diseases,” Scheperjans concluded.

The study, titled “Antibiotic exposure and risk of Parkinson's disease in Finland: A nationwide case-control study”, was published online on 18 November 2019 in Movement Disorders, ahead of inclusion in an issue.

Tags:

To post a reply please login or register

Study links face-to-face dentistry restrictions to increased antibiotic prescription

MANCHESTER, UK: Dental guidelines in the UK, as in many countries, are predicated upon the knowledge that dental infections respond better to treatment ...

Researchers employ AI to investigate links between oral health and cardiovascular disease

STONY BROOK, N.Y., US: The applicability and efficacy of artificial intelligence (AI) within dentistry appears to be limitless. With each passing day, ...

Researchers find link between obesity and periodontal disease

CLEVELAND, U.S.: Obesity and periodontal disease remain the most common noncommunicable diseases in the U.S. A recent study has explored the effect of ...

Periodontal disease increases risk of chronic diseases, including mental ill health

BIRMINGHAM, UK: In a recent study, researchers from the University of Birmingham examined the records of patients having a history of periodontal disease, ...

Researchers link amoeba to severe periodontitis

BERLIN, Germany: For the first time, researchers from Charité—Universitätsmedizin Berlin have shown that the amoeba Entamoeba gingivalis, commonly found...

Extensive study links e-cigarette use with increased risk of heart failure

WASHINGTON, US: In recent years, there has been an increase in studies on vaping and its link to oral and overall health. Adding to existing research, a new...

Global strategies are needed to reduce inappropriate antibiotic use

MURCIA, Spain: The World Health Organization annually publishes data on defined daily dose per 1,000 inhabitants per day (DID) for antibiotics, allowing ...

Researchers and dentists join forces to increase durability of dental fillings

BERLIN/POTSDAM, Germany: Even though dentistry has come a long way, the majority of dental restorations do not last owing to the demineralisation of the ...

New research uses squid ink to check for periodontal disease

SAN DIEGO, USA: An engineer-led team has developed a new dental imaging method to examine the health of patients’ gingivae. A mixture of squid ink, water ...

Study supports use of preventative antibiotic use in high-risk patients

SHEFFIELD, UK: Currently, the National Institute for Health and Care Excellence (NICE) guidelines recommend that dentists should generally not use ...

Education

Live webinar
Thu. 11 September 2025
1:00 pm EST (New York)