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Interview: “Bioactive endodontics is the future”

Dr. James Bahcall and colleagues are exploring the possibilities of cryotherapy in endodontic dentistry. (Photograph: Dr. James Bahcall)
Monique Mehler, Dental Tribune International

Monique Mehler, Dental Tribune International

Mon. 8. July 2019

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In the medical field, cryotherapy is used in an effort to relieve pain and swelling after soft-tissue management or surgery. Currently, researchers in the U.S. are exploring the possibilities and limitations of vital pulp cryotherapy in clinical trials. Dr. James Bahcall, who plays an important role in these investigations, is a clinical professor at the University of Illinois at Chicago. He spoke to Dental Tribune International about the studies.

Dr. Bahcall, in collaboration with other researchers, you have published an article titled “Introduction to vital pulp cryotherapy” in which the use of cold therapy in endodontics is explored. What is the history behind the use of  cryotherapy in vital pulp therapy?
There has been a paradigm shift in vital pulp therapy over the last three to five years. We have gained a better understanding of pulp biology from caries involvement, and there have been new developments in bioceramic materials. We have also come to view vital pulp therapy as a permanent rather than temporary dental treatment. All of this allowed us to develop vital pulp cryotherapy. Although we did not invent cryotherapy, we were the first to bring it into endodontics for vital pulp treatment. Medicine has demonstrated since the early 1960s that cryotherapy can reduce nerve pain response, inflammation and hemorrhaging, and can help reduce a patient’s need for postoperative pain medications.

Vital pulp cryotherapy is performed when a carious lesion is removed from a tooth and there is direct or indirect exposure of the dental pulp. The cryotherapy portion of treatment involves placing sterile ice on the exposed pulp. The application of ice lowers the temperature of the tooth’s blood and nerve supply, and this has been shown clinically to reduce inflammation and post-treatment tooth pain. It is important to note that, after performing the cryotherapy procedure, 17% EDTA irrigation is applied, a bioceramic material is then placed over the directly or indirectly exposed pulp, and the tooth is restored with a permanent restorative material, such as composite or amalgam.

How is this different from classic root canal therapy?
Vital pulp cryotherapy involves treating a carious tooth while maintaining the tooth’s pulpal tissue as opposed to root canal therapy that involves removal of the entire dental pulp and replacing it with gutta-percha and sealer.

What are the benefits of vital pulp cryotherapy, and what are its limitations?
The benefits of vital pulp cryotherapy are its ability to eliminate pulpal inflammation and a patient’s tooth pain without the complete removal of the dental pulp. By maintaining the dental pulp, we are able to maintain the tooth’s strength by not having to remove root dentin, the pulp–dentin complex and the pulp’s immune defense mechanisms. Another benefit of vital pulp cryotherapy is the treatment time for the patient. Once the patient is properly anesthetized and the caries is removed, the actual time to complete the vital pulp cryotherapy portion is 10–15 minutes. In comparison, root canal therapy can take 1–2 hours. Vital pulp therapy procedures are completed in one patient treatment visit.

The limitation of vital pulp cryotherapy is that this procedure can only be performed on vital teeth that can be permanently restored with composite or amalgam immediately after the procedure. It cannot be performed with necrotic or partially necrotic pulps. A clinician cannot prepare a vital pulp cryotherapy treated tooth for a crown. The reason for this is that, once the vital pulp cryotherapy is completed, you do not want to do any further dental treatment to this tooth because you risk the possibility of restimulating the pulpal inflammation.

In your article, you conclude that further clinical studies are needed in order to establish the long-term prognosis of a pulp after vital pulp cryotherapy. What are your expectations?
As with any new dental procedure, clinical cases and studies need to be published in peer-reviewed dental literature. Vital pulp cryotherapy is no different. We have published case reports and have been conducting clinical research on vital pulp cryotherapy. Our study has found that patients have less postoperative pain immediately after treatment and maintain normal pulp vitality at six months and at one year after treatment. This is as far as our clinical study has patient recalls at this point. Our expectations are, firstly, to demonstrate that this is a valid procedure for vital pulp treatment beyond one year. Secondly, we hope to encourage our dental colleagues to publish vital pulp cryotherapy case reports and clinical research in the dental literature.

How do you think vital pulp cryotherapy will advance endodontics?
We feel that vital pulp cryotherapy will help to broaden the type of pulpal treatment that we can provide to our patients. It also will be an important treatment component in bioactive endodontic therapy. Bioactive endodontics is the future. By definition, “bioactive” means having a biological effect. Bioactive endodontics in conventional endodontic treatment includes vital pulp cryotherapy and regenerative endodontics. It involves the use of bioactive materials and the patient’s own blood to help heal, as in the case of vital pulp cryotherapy, and to replace the gutta-percha and sealer in classic root canal therapy.

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Fig. 1: Pre-op emergency presentation showing a fractured ceramic veneer on tooth #21. (All images: Dr Wiktor Pietraszewski)

Tue. 31. March 2026

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In my experience, the cementation of glass-ceramic veneers is one of the most technique-sensitive procedures in restorative dentistry, owing to the minimal margin for error and the high aesthetic standards required to achieve a result that satisfies both clinician and patient. Current protocols emphasise conservative preparation, ideally remaining entirely within the enamel or, at the very least, minimising extension into the dentine. Preparation design and extent should not be planned in isolation, but coordinated through close collaboration between clinician and technician, ensuring that the final result is both biologically sound and aesthetically predictable.

Clinical presentation and treatment background

The case presented in this article is unusual in that it arose unexpectedly, without typical pretreatment planning steps such as a diagnostic wax-up or mock-up. These were omitted because of time and budget constraints on the patient’s part—a reality to which many clinicians can relate. Financial considerations often limit acceptance of comprehensive treatment plans; therefore, phased planning and effective communication are essential in fostering patient trust and long-term commitment. The rationale for this approach in the present case will become clearer as the case unfolds.

The patient was a 70-year-old female retiree whom I had been treating for several years. Treatment up to that point had focused on stabilising and gradually improving her posterior restorations, and the longer-term aim was to address the anterior dentition to enhance both function and aesthetics. The patient presented for an emergency appointment with a fractured porcelain veneer on tooth #21 (Fig. 1). Owing to the existing phased approach to her care, it was possible to transition into aesthetic restoration with minimal resistance or hesitation by the patient.

Fig. 2: Treatment planning using digital smile design, including four porcelain veneers and four direct composite restorations.

Fig. 2: Treatment planning using digital smile design, including four porcelain veneers and four direct composite restorations.

Treatment planning and objectives

After careful discussion, it was decided to remove and replace the four existing porcelain veneers and to replace four existing Class V stained composite restorations with new direct composite restorations. The proposed plan was considered appropriate for meeting the patient’s aesthetic expectations.

At the emergency appointment, time was limited, and only temporary restoration of the fractured veneer with direct composite was feasible. Time remained an important factor because the patient wished to complete treatment as soon as possible.

Tooth preparation, digital workflow and provisional restorations

Guided by the digital smile design plan (Fig. 2), the teeth were built up with a flowable composite to create a rough direct mock-up (Fig. 3). This mock-up provided a visual and functional prototype, from which an impression was taken to fabricate provisional restorations. These provisional restorations were placed after tooth preparation and worn until delivery of the definitive veneers.

Tooth preparation was carried out with an OptraGate latex-free lip and cheek retractor (Ivoclar) in place. The existing veneers were removed using high-grit diamond burs at high speed. Once the bulk of the material had been removed, gingival retraction was achieved with retraction cord to improve visibility and access. The preparations were then refined with lower-grit diamond burs at reduced speed to ensure precision and tissue safety. The primary objectives were to cover the cervical defects evident in the previous restorations (Fig. 4) and to establish harmonious gingival zeniths after preparation (Fig. 5).

Fig. 3: Additive mock-up fabricated using a flowable composite to evaluate the proposed aesthetic outcome.

Fig. 3: Additive mock-up fabricated using a flowable composite to evaluate the proposed aesthetic outcome.

Fig. 4: Clinical situation after replacement of the Class V composite restorations on teeth #13, 23, 24 and 25.

Fig. 4: Clinical situation after replacement of the Class V composite restorations on teeth #13, 23, 24 and 25.

Fig. 5: Clinical situation after preparation of the maxillary incisors.

Fig. 5: Clinical situation after preparation of the maxillary incisors.

Material selection and considerations for veneer cementation

Glass-ceramic veneers have traditionally been cemented using a wide range of resin cements. Recently, the use of flowable or preheated paste resin composite for cementation has gained attention.

Fig. 6: PANAVIA V5 try-in paste Universal (A2) for shade evaluation.

Fig. 6: PANAVIA V5 try-in paste Universal (A2) for shade evaluation.

A key advantage of this approach is clinicians’ familiarity with composite shade systems, typically based on the VITA classical A1–D4 guide (VITA Zahnfabrik), which many clinicians find more intuitive than resin cement shade designations such as “warm”, “light” or “neutral”. To address this limitation, some resin cement systems offer try-in pastes corresponding to cement shades, enabling accurate evaluation during try-in. PANAVIA Veneer LC (Kuraray Noritake Dental) is one such system, and PANAVIA V5 try-in pastes correspond to its shades (Fig. 6).

Using a cement shade that matches the intended final appearance is crucial when bonding glass-ceramic veneers because it decisively affects both immediate and long-term aesthetics, particularly owing to the light diffusion properties of glass-ceramic materials such as IPS e.max CAD and IPS e.max Press (both Ivoclar). In minimally invasive cases, restorations can be as thin as 0.3 mm. The thinner and more translucent the restoration, the greater the influence of the cement shade on the final outcome.

Fig. 7: Selection of IPS e.max translucency to support shade matching and masking of the underlying tooth structure.

Fig. 7: Selection of IPS e.max translucency to support shade matching and masking of the underlying tooth structure.

The shade of the prepared tooth also substantially affects cement selection, as do decisions regarding restoration thickness and ceramic translucency. IPS e.max is available in low translucency, medium translucency and high translucency (Fig. 7). When the prepared teeth are dark and a brighter result is desired, selecting a ceramic with lower translucency is advisable. Documenting the prepared teeth photographically and sharing this information with the ceramist is therefore essential.

In the present case, the prepared tooth structure appeared relatively dark in the incisal third. A medium-translucency IPS e.max CAD material in Shade A1 was therefore selected to allow minimal thickness while achieving a natural outcome.

Material overview: PANAVIA Veneer LC system

Based on the considerations for veneer cementation, PANAVIA Veneer LC was selected. This light-polymerising resin cement is indicated for ceramic and composite restorations of less than 2 mm in thickness. It is available in four shades—Clear, Universal (A2), White and Brown (A4; Fig. 8a)—and PANAVIA V5 try-in pastes are available in corresponding shades (Fig. 8b), enabling simulation of the final restoration appearance. The system consists of four components: a 35% phosphoric acid etching gel (K-ETCHANT Syringe, Kuraray Noritake Dental), a tooth primer (PANAVIA V5 Tooth Primer), a ceramic primer (CLEARFIL CERAMIC PRIMER PLUS, Kuraray Noritake Dental) and PANAVIA Veneer LC paste (Figs. 9a–d).

Figs. 8a & b: Available shades of PANAVIA Veneer LC paste (a) and the corresponding PANAVIA V5 try-in pastes (b).

Figs. 8a & b: Available shades of PANAVIA Veneer LC paste (a) and the corresponding PANAVIA V5 try-in pastes (b).

Figs. 9a–d: Cementation system: phosphoric acid etchant (a), resin cement paste (b), ceramic primer (c) and tooth primer (d).

Figs. 9a–d: Cementation system: phosphoric acid etchant (a), resin cement paste (b), ceramic primer (c) and tooth primer (d).

Try-in procedure and shade selection

After fabrication of the four lithium disilicate veneers in the selected translucency and shade (Fig. 10), the resin cement shade was evaluated. A bright result that would harmonise with the adjacent dentition was desired; therefore, the Universal shade was selected. The patient and clinical team were satisfied with the simulated outcome (Fig. 11), and the veneers were cleaned and pretreated for definitive placement.

Fig. 10: Laboratory-fabricated IPS e.max CAD veneers prior to clinical try-in, showing medium translucency.

Fig. 10: Laboratory-fabricated IPS e.max CAD veneers prior to clinical try-in, showing medium translucency.

Fig. 11: Clinical try-in of the veneers using PANAVIA V5 try-in paste Universal (A2) to assess fit and shade integration.

Fig. 11: Clinical try-in of the veneers using PANAVIA V5 try-in paste Universal (A2) to assess fit and shade integration.

Adhesive cementation protocol

For adhesive cementation of the veneers, the teeth were isolated using a latex-free dental dam (Isodam HD, heavy gauge, Four D; Fig. 12). After placement of the dental dam, clamps were placed and the veneers tried in again to confirm fit (Figs. 13a & b).

Afterwards, tooth surface pretreatment began with the central incisors. Adjacent teeth were protected with a metal strip, and air abrasion with a 35 μm aluminium oxide powder was performed (Fig. 14a). After roughening of the surface (Fig. 14b), the phosphoric acid etching gel was applied and left for 15–30 seconds (Fig. 15), followed by thorough rinsing and drying. The lateral incisors were then isolated with PTFE tape to facilitate removal of excess cement (Fig. 16).

The actual cementation steps included priming of the tooth structure with PANAVIA V5 Tooth Primer (Fig. 17), left for 20 seconds and gently air-dried. The intaglio surfaces of the veneers were treated with hydrofluoric acid for 20 seconds and, after thorough rinsing, primed with CLEARFIL CERAMIC PRIMER PLUS (Fig. 18) and dried.

PANAVIA Veneer LC was then applied to the pretreated ceramic surfaces, and the veneers were seated carefully (Figs. 19a & b). Gentle, controlled pressure using a soft instrument ensured accurate seating. When light-polymerising resin cements are used, excess material can often be removed prior to polymerisation, thereby reducing excess and simplifying clean-up.

The resin cement provides a seamless marginal transition between tooth and restoration, enhancing both aesthetic and functional integration of the veneers. Glycerine gel was applied to the restoration margins before light polymerisation to prevent formation of an oxygen inhibition layer (Fig. 19c).

The lateral incisor veneers were cemented in the same manner; however, floss was used for gingival retraction instead of clamps (Figs. 20a & b). Sequencing the procedure by first cementing the central incisors and subsequently the lateral incisors is recommended. This protocol gives the practitioner full control over the positioning of the central incisor veneers, which is particularly important because their position has a considerable impact on the overall appearance of the smile. When the lateral incisor veneers are cemented first, the risk of positioning errors in the central incisor region and resulting aesthetic issues is increased. However, any error with the positioning of the central incisor veneers can also lead to problems such as the misfit of the lateral incisor veneers. Therefore, the whole procedure needs to be carried out with utmost care and precision.

A comprehensive polymerisation protocol, including palatal, incisal and facial light exposure, is necessary to ensure complete polymerisation. After placement of the veneers, excess cement was removed using ultra-high molecular weight polyethylene floss (Gorilla Floss, Erskine Products) to protect the margins (Figs. 21a–c). Final polishing of the ceramic–tooth interface was performed using polishing rubbers. The dental dam remained stable throughout the procedure.

Fig. 22: Immediate postoperative result after cementation, showing mild gingival erythema, consistent with a transient tissue response after adhesive procedures.

Fig. 22: Immediate postoperative result after cementation, showing mild gingival erythema, consistent with a transient tissue response after adhesive procedures.

Fig. 23: Follow-up after three weeks showing complete soft-tissue healing, stable marginal integration and healthy gingival contours.

Fig. 23: Follow-up after three weeks showing complete soft-tissue healing, stable marginal integration and healthy gingival contours.

The immediate outcome after cementation showed slightly erythematous and tender gingival tissue, reflecting a transient response to the adhesive procedure (Fig. 22). This represents a temporary tissue response and typically improves over the following days as healing progresses. With a consistent and appropriate oral hygiene routine, full recovery of the soft tissue can be expected. This should be clearly communicated to the patient after removal of the dental dam.

Fig. 24a: Final aesthetic outcome. Frontal close-up view showing symmetry and surface texture.

Fig. 24a: Final aesthetic outcome. Frontal close-up view showing symmetry and surface texture.

Fig. 24b: Lateral view from the left side.

Fig. 24b: Lateral view from the left side.

Fig. 24c: Lateral view from the right side.

Fig. 24c: Lateral view from the right side.

Fig. 24d: Palatal view.

Fig. 24d: Palatal view.

Clinical follow-up

At the follow-up appointment, soft-tissue healing and patient adaptation were assessed. The gingival tissue had fully recovered after three weeks (Fig. 23). This visit also provided an opportunity for final photographic documentation (Figs. 24a–d). At this appointment, careful evaluation of the interproximal areas is essential to detect any residual cement, which may result in chronic inflammation and compromise aesthetics. Inspection from the occlusal aspect helps ensure complete removal of excess material and supports long-term gingival health.

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