Dental News - Novel adhesive patch helps treat oral lichen planus and recurrent aphthous stomatitis

Dental Tribune International

Mon. 27. March 2023

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BOSTON, US: Oral lichen planus and recurrent aphthous stomatitis are common chronic inflammatory conditions that can affect patients’ quality of life. Since current treatment approaches are mainly palliative and often ineffective owing to insufficient contact time of the therapeutic agent with the lesions, researchers have recently developed an adhesive patch to improve retention in the oral cavity and enable sustained release of clobetasol-17-propionate, the first-line drug for treating both conditions.

In the study, the researchers—from the Harvard School of Dental Medicine in Boston—also examined the properties of the novel bio-inspired adhesive patch, called Dental Tough Adhesive (DenTAl), regarding adhesion to diverse oral tissues. They subjected DenTAl to ex vivo mechanical testing, assessed its biocompatibility in vitro and adhesion in vivo and ex vivo, and investigated its drug release in vitro when loaded with clobetasol.

They found that DenTAl has superior physical, such as stretchability, and adhesive properties compared with existing oral technologies and is capable of strong adhesion to different kinds of wet and dynamic intra-oral tissue. They also reported that the clobetasol was released in a tunable sustained manner for up to four weeks and demonstrated immunomodulatory capabilities in vitro, resulting in reductions in several pro-inflammatory cytokines.

The study’s findings suggest that DenTAl may be a promising device for the intra-oral delivery of small-molecule drugs for the management of painful oral lesions associated with chronic inflammatory conditions such as oral lichen planus and recurrent aphthous stomatitis. The researchers said that future clinical applications may include delivery of antimicrobial and chemotherapeutic agents to treat periodontitis and precancerous or malignant lesions.

The study, titled “Tough adhesive hydrogel for intraoral adhesion and drug delivery”, was published online on 8 March 2023 in the Journal of Dental Research, ahead of inclusion in an issue.

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