CHENGDU, China: Research has shown a connection between severe periodontal disease and the progression of chronic obstructive pulmonary disease (COPD). However, the specifics of how this relationship affects the immune system are not yet fully understood. Shedding new insights on the topic, a new study has reported that immune system cells play a crucial role in the microbial link between COPD and periodontal disease.
The researchers, from Sichuan University in China, reported that bacteria associated with periodontal disease promote COPD through the activation of two types of immune system cells: gamma-delta (γδ) T cells, white blood cells that can respond quickly to infected or cancerous cells, and M2 macrophages, white blood cells that help heal wounds and reduce inflammation. They believe that concentrating on this particular mechanism could present innovative approaches for the prevention and management of COPD.
“By enhancing periodontal therapy and targeting the inhibition of γδ T cells and M2 macrophages [we] may be able to help control the progression of COPD,” co-author Dr Boyu Tang, a microbiologist at the West China Hospital of Stomatology at Sichuan University, said in a press release.
COPD is a lifelong disease that has no cure. According to the World Health Organization, it is the sixth-leading cause of death worldwide. In countries with higher income levels, smoking tobacco is the primary contributor to COPD, whereas in low- and middle-income countries, both tobacco smoking and domestic air pollution play major roles as risk factors.
Previous studies have shown that Porphyromonas gingivalis plays an important role in periodontal disease. In the present study, the researchers demonstrated how this bacterium could aggravate the progression of COPD. In one of their experiments, they infected mice in which they had induced COPD with P. gingivalis and found that this resulted in worse progression of the COPD compared with mice with COPD only. Another experiment showed that when mice were orally exposed to P. gingivalis, the bacteria moved to and infected their lung tissue. This resulted in a notable alteration in the lung microbiota. Further observations revealed that periodontitis promoted the expansion of the immune cells in the lung tissue.
In yet another experiment, the researchers were able to show that P. gingivalis could activate the immune cells, thus promoting their ability to produce cytokines associated with worsening COPD.
Future studies on human subjects are underway to validate the findings. The researchers are planning to recruit patients with both COPD and periodontal disease and offer them periodontitis treatment. They would then compare the participants’ lung function and immune cell counts before and after treatment.
“Our finding could lead to a potential new strategy for treating COPD,” Li concluded.
The study, titled “Periodontitis aggravates COPD through the activation of γδ T cell and M2 macrophage”, was published online on 12 January 2024 in mSystems, ahead of inclusion in an issue.
Tags:
According to current data, approximately ten million people in Germany have severe periodontitis. This condition leads to tooth extractions and loss of ...
LONDON, UK: Factors such as glucose metabolism, nutrition, oxidative stress and ageing drive periodontal progression. However, current periodontal ...
As the elderly population continues to grow exponentially, it is now more important than ever to address certain challenges related to the oral and overall ...
LAHORE, Pakistan: Because treating periodontal disease requires a nuanced approach, a means of predicting the most likely treatment requirements could help ...
MELBOURNE, Australia: The value of mouthwash as part of routine oral hygiene has often been questioned in the literature. Seeking to provide the most ...
LEIPZIG, Germany: As the COVID-19 pandemic has progressed, more and more has been discovered about the virus and disease. Previously, it was assumed that ...
BALTIMORE, U.S: Scientists investigating the potential health effects of vaping on the human pulmonary system have reported that inhaling vapor from ...
Live webinar
Mon. 29 April 2024
12:30 pm EST (New York)
Prof. Roland Frankenberger Univ.-Prof. Dr. med. dent.
Live webinar
Tue. 30 April 2024
1:00 pm EST (New York)
Live webinar
Fri. 3 May 2024
1:00 pm EST (New York)
Live webinar
Tue. 7 May 2024
8:00 pm EST (New York)
Live webinar
Thu. 9 May 2024
8:00 pm EST (New York)
Live webinar
Mon. 13 May 2024
9:00 am EST (New York)
Live webinar
Mon. 13 May 2024
1:00 pm EST (New York)
Doc. MUDr. Eva Kovaľová PhD.
Brazil / Brasil
Canada / Canada
Latin America / Latinoamérica
USA / USA
Austria / Österreich
Bosnia and Herzegovina / Босна и Херцеговина
Bulgaria / България
Croatia / Hrvatska
Czech Republic & Slovakia / Česká republika & Slovensko
France / France
Germany / Deutschland
Greece / ΕΛΛΑΔΑ
Italy / Italia
Netherlands / Nederland
Nordic / Nordic
Poland / Polska
Portugal / Portugal
Romania & Moldova / România & Moldova
Slovenia / Slovenija
Serbia & Montenegro / Србија и Црна Гора
Spain / España
Switzerland / Schweiz
Turkey / Türkiye
UK & Ireland / UK & Ireland
China / 中国
India / भारत गणराज्य
Japan / 日本
Pakistan / Pākistān
Vietnam / Việt Nam
ASEAN / ASEAN
Israel / מְדִינַת יִשְׂרָאֵל
Algeria, Morocco & Tunisia / الجزائر والمغرب وتونس
Middle East / Middle East
Prof. Roland Frankenberger Univ.-Prof. Dr. med. dent.Register now1CELive webinar
Dr. Luis TovimRegister now1CELive webinar
Dr. Lawrence BrechtLive webinar
Dr. Bruno JhamRegister now1CE:sharpen(level=0):output(format=webp)/up/dt/2024/04/Shutterstock_1017664873.jpg "Nuvola aligners combined with a myofunctional device in paediatric treatment: A case report")
:sharpen(level=0):output(format=webp)/up/dt/2024/04/Treating-periodontal-disease-reduces-atrial-fibrillation-recurrence.jpg "Treating periodontal disease reduces atrial fibrillation recurrence")
:sharpen(level=0):output(format=webp)/up/dt/2024/04/3Shape-charts-sustainable-course-with-release-of-comprehensive-sustainability-report-2023.jpg "3Shape releases comprehensive sustainability report for 2023")
:sharpen(level=0):output(format=webp)/up/dt/2024/04/Zumax-Medical-Image-1.jpg "Zumax Medical: From endodontics to general dentistry")
:sharpen(level=0):output(format=webp)/up/dt/2024/04/IDEM-2024-Wraps-up-its-13th-edition-with-record-breaking-success.jpg "IDEM 2024 delivers on “Exceptional Dentistry: Techniques, Technologies and Trends”")
:sharpen(level=0):output(format=webp)/up/dt/2022/10/DMP-logo-2020_end.png "DMP DENTAL INDUSTRY"){kind=logo}
:sharpen(level=0):output(format=webp)/up/dt/2022/01/Ivoclar_Logo_19-01-2022.png "Ivoclar"){kind=logo}
:sharpen(level=0):output(format=webp)/up/dt/2014/02/FKG.png "FKG Dentaire")
:sharpen(level=0):output(format=webp)/up/dt/2022/01/HASSBIO_Logo_horizontal.png "HASSBIO"){kind=logo}
:sharpen(level=0):output(format=webp)/up/dt/2023/06/Align_logo.png "Align Technology"){kind=logo}
:sharpen(level=0):output(format=webp)/up/dt/2024/01/Periodontal-disease-worsens-chronic-obstructive-pulmonary-disease.jpg "Periodontal disease worsens chronic obstructive pulmonary disease")
:sharpen(level=0):output(format=webp)/up/dt/2024/04/Shutterstock_1017664873.jpg "Nuvola aligners combined with a myofunctional device in paediatric treatment: A case report")
:sharpen(level=0):output(format=webp)/wp-content/themes/dt/images/dt-user.gif "Dental Tribune International")
:sharpen(level=0):output(format=webp)/up/dt/2024/01/Fig.-1.jpg "Treatment of patients with severe periodontal disease in general dental practice")
:sharpen(level=0):output(format=webp)/up/dt/2023/10/Metformin-could-help-prevent-oral-and-systemic-disease-in-periodontal-patients.jpg "Metformin could help prevent oral and systemic disease in periodontal patients")
:sharpen(level=0):output(format=webp)/up/dt/2023/09/Maintaining-good-dental-and-oral-health-is-crucial-for-lifelong-quality-of-life.jpg "“Maintaining good dental and oral health is crucial for lifelong quality of life”")
:sharpen(level=0):output(format=webp)/up/dt/2023/09/Artificial-intelligence-takes-early-steps-in-predicting-post-treatment-periodontal-disease-severity.jpg "Artificial intelligence takes early steps in predicting post-treatment periodontal disease severity")
:sharpen(level=0):output(format=webp)/up/dt/2024/01/New-journal-supplement-explores-the-role-of-mouthwash-in-oral-care.jpg "New journal supplement explores the role of mouthwash in oral care")
:sharpen(level=0):output(format=webp)/up/dt/2021/05/SARS-Cov-2-virus-might-enter-lungs-through-gums-experts-say_780-x-439.jpg "SARS-CoV-2 might enter lungs through gingivae, experts say")
:sharpen(level=0):output(format=webp)/up/dt/2020/01/Vaping-increases-odds-of-asthma-and-COPD.jpg "Scientists find adverse pulmonary health effects associated with vaping")
:sharpen(level=0):output(format=webp)/up/dt/2024/04/Shutterstock_1017664873.jpg "Nuvola aligners combined with a myofunctional device in paediatric treatment: A case report")
:sharpen(level=0):output(format=webp)/up/dt/2024/04/Treating-periodontal-disease-reduces-atrial-fibrillation-recurrence.jpg "Treating periodontal disease reduces atrial fibrillation recurrence")
:sharpen(level=0):output(format=webp)/up/dt/2024/04/3Shape-charts-sustainable-course-with-release-of-comprehensive-sustainability-report-2023.jpg "3Shape releases comprehensive sustainability report for 2023")
:sharpen(level=0):output(format=webp)/wp-content/themes/dt/images/3dprinting-banner.jpg "3D Printing Banner")
:sharpen(level=0):output(format=webp)/wp-content/themes/dt/images/aligners-banner.jpg "3D Printing Banner")
:sharpen(level=0):output(format=webp)/wp-content/themes/dt/images/covid-banner.jpg "3D Printing Banner")
:sharpen(level=0):output(format=webp)/wp-content/themes/dt/images/roots-banner-2024.jpg "3D Printing Banner")
To post a reply please login or register