Dental News - Researchers to develop biodegradable strip and gel to prevent bone loss in periodontitis

Dental Tribune International

Tue. 27. August 2019

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NEW YORK, U.S.: In a step that may help redefine the treatment of periodontitis, researchers at New York University College of Dentistry (NYU Dentistry) startup company Periomics Care have been awarded a one-year grant to develop an oral strip and gel to treat the disease. The grant, which began Aug. 1, 2019, and totals $224,000, was provided by the National Institute of Dental and Craniofacial Research and will be used specifically to help prevent bone loss in people with Type 2 diabetes.

With periodontitis five times more likely in patients with Type 2 diabetes than in those without, researchers hope that they can develop a treatment that not only improves outcomes but also reduces pain. “There is a major void in therapeutic products for periodontal disease that target the underlying mechanism of disease—and are easy for dentists and patients to use,” said Dr. Angela Kamer, Associate Professor of Periodontology and Implant Dentistry at NYU Dentistry and a consultant on the project.

In a previous study by researchers at Periomics Care, scientists found that a metabolite called succinate is elevated in people with diabetes and activates succinate receptor 1 (SUCNR1). The study demonstrated that blocking SUCNR1 activation controls inflammation and periodontal bone loss, suggesting that SUCNR1 would be a useful target for developing therapies to prevent periodontal bone loss. With this in mind, a new team of researchers aim to develop a sustained-release oral strip and gel formulation to target the protein.

According to researchers, the oral strip and gel will use biodegradable material filled with a SUCNR1 antagonist, a method protected by a provisional U.S. patent. The strip would be implanted by a dentist, while patients would apply the topical gel to their gingivae themselves. “The development of a biodegradable oral strip or gel formulation that could be administered through less invasive approaches to augment or replace conventional treatment could prove to be a major step forward in the treatment of periodontal disease,” said Dr. Deepak Saxena, Associate Professor of Basic Science and Craniofacial Biology at NYU Dentistry and Director of Periomics Care.

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