Background: Melatonin, a hormone produced primarily in the pineal gland, possesses a series of biological properties that appear to have an influence on bone homeostasis. Currently, little is known about how melatonin influences bone metabolism in periodontology and implantology.
Objective: The objectives of this study are (1) to review the properties of melatonin in regulating bone homeostasis; (2) to discuss its direct and indirect e ects on bone; and (3) to propose mechanisms for the use of melatonin as an agent to promote alveolar bone regeneration.
Conclusion: Melatonin positive regulation of bone formation and homeostasis, in combination with the inhibitory effects on bone resorption, highlights the potential use of melatonin as a marker of periodontal and periimplant bone-related diseases. In vitro and animal studies show promising results on the use of melatonin as a regenerative agent, although no clinical studies have yet been performed.
Editorial note: The full article was published in the 2/2016 issue of the Journal of Oral Science and Rehabilitation. Access the full article at www.dtscience.com.
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